Where to buy Prednisone online
|Drug Name:||Generic Prelone (Prednisolone)||Generic Prednisone|
|Tablet Strength:||5mg, 10mg, 20mg, 40mg||10mg, 20mg, 40mg|
|Available Packages:||30, 60, 90, 120, 180, 270, 360 pills||30, 60, 90, 120, 180, 270 pills|
|Payment Method:||VISA, MASTERCARD||VISA, MASTERCARD|
|Shipment:||Express Delivery Service||Express Delivery Service|
|Buy Now From:||EuroDrugPharmacy||Euro-PharmacyOnline|
Prednisone: pharmacological action of the drug
Hormonal steroid drugs belong to the class of strong substances. The minimum concentrations of such drugs are sufficient for a marked change in the functioning of various organs and systems.
Therefore, such funds are prescribed only for strict indications, when the action of non-hormonal drugs is not enough to stop inflammatory, allergic, autoimmune, and other processes that have complex pathogenesis of development.
However, there are a number of diseases in which the use of various forms of the drug Prednisone, as well as other drugs of the corticosteroid class, is a vital necessity. The adrenal cortex produces about 40 different hormones, which can be divided into several groups.
These are glucocorticoids, mineralocorticoids, estrogens, and androgens. They differ greatly in their functions, but the common precursor of these biologically active compounds is cholesterol, and the regulation of corticosteroid synthesis is under the control of the hypothalamic-pituitary system, namely the adrenocorticotropic hormone. The main hormone of the adrenal cortex is cortisol. It is usually released in a concentration of 15-30 mg, which significantly exceeds the number of other secreted biologically active compounds. When the level of cortisol falls below the physiological norm, as well as against the background of stressful situations for the body (wounds, accompanied by severe pain, an infectious process, physical activity), a specific substance called corticoliberin is produced in the hypothalamus.
What is Prednisone’s effect on the body?
It activates the secretion of the adrenocorticotropic hormone, which affects the functioning of the adrenal cortex. When cortisol reaches the norm, the development of corticotropin suspends. That is why the release of this substance is not constant throughout the day. Its maximum amount is released in the morning, and its minimum secretion intensity reaches in the evening and at night.
By the way, such a cyclical work of the adrenal cortex is determined by the scheme of the reception of corticosteroids. It is difficult to overestimate the importance of adrenal cortex hormones for the normal functioning of all organs and systems without exception. We should mention that the animal died a few days after the experimental removal of secreting glucocorticosteroids tissue.
Prednisone is a synthetic analog of hydrocortisone, which has a similar effect on this hormone in the body (so it is often used as a substitute for natural biologically active substances of the adrenal cortex). It is more effective than drugs obtained by natural means. So, it can be used in lower doses to achieve a therapeutic result. Prednisone is absorbed less when applied topically.
Prednisone has such an effect on the human body:
- antiallergic (desensitizing)
How does Prednisone fight against inflammation?
Inflammation is a very complex process in which many tissues are involved at the cellular level. The development of such pathology involves mast cells, various types of lymphocytes, cells of the internal endothelium of blood vessels, and platelets. They produce a variety of biological components, which cause the symptoms of an inflammatory reaction.
The drug also has the ability to strengthen the membranes of mast cells and reduce the level of proliferation in connective tissue, which is important for the treatment of rheumatoid arthritis and other joint diseases. Prednisone narrows small blood vessels and the level of fluid exudation falls (this leads to a decrease in inflammatory edema), the accumulation of leukocytes in the lesion is suspended, the body temperatures, the rate of erythrocyte sedimentation and, other objective and laboratory indicators of inflammation decrease.
The immunosuppressive and desensitizing effect, which Prednisone has, is associated with the overwhelming effect of the drug on the activity of T- and B-type lymphocytes and cytokine synthesis, a decrease in the level of freely circulating lymphocytes and macrophages in the bloodstream. Due to this effect, Prednisone in the form of droppers or intramuscular injections is prescribed to eliminate the shock state and manifestations of an acute allergic reaction.
For example, a prick of Prednisone acts much faster than sprays with other corticosteroid drugs with an exacerbation of bronchial asthma and other complications caused by spasm and edema of the smooth muscles of the respiratory system. When taken orally, the active substance of the drug binds to specific cell receptors, which are present in all tissues without exception.